Nattokinase Supplements: Guide

Nattokinase, an enzyme found in fermented soybeans (natto), is becoming a popular supplement, particularly for its cardiovascular benefits. Traditionally used in Japan, nattokinase has gained recognition in the wellness community for its potential to support heart health and improve circulation. Today, nattokinase supplements offer a convenient and accessible way to benefit from this natural enzyme.

At Health Orchard, we aim to provide in-depth health insights, and understanding nattokinase supplements is essential for anyone looking to improve their cardiovascular well-being. This article will explore the benefits, uses, dosage recommendations, and risks associated with nattokinase.

What is Nattokinase?

Nattokinase is an enzyme that naturally forms during the fermentation process of soybeans into natto, a traditional Japanese food. Natto has long been recognized in Japan for its nutritional value and unique health benefits, particularly for heart health. Unlike many enzymes, nattokinase remains active after digestion, allowing it to perform its functions once absorbed into the bloodstream. It is extracted from the fermentation process of natto by a bacterium called Bacillus subtilis and has gained popularity for its role in cardiovascular health management. The enzyme was first discovered by Dr. Hiroyuki Sumi in the 1980s, who noticed its ability to break down blood clots in vitro, sparking a wave of research into its potential therapeutic applications.

The primary mechanism through which nattokinase works involves breaking down fibrin, a protein essential for blood clot formation. Fibrin plays a crucial role in wound healing, but when too much accumulates, it can lead to the formation of dangerous blood clots, which in turn increases the risk of heart attacks, strokes, and deep vein thrombosis. Nattokinase’s fibrinolytic activity, or the ability to dissolve fibrin, makes it valuable in maintaining healthy circulation. By helping to regulate fibrin levels, nattokinase reduces the chances of clot formation, promoting smoother blood flow and lowering the risk of cardiovascular issues. Its natural origin and ease of absorption make it an appealing option for those seeking alternatives to pharmaceutical blood thinners.

Key Health Benefits of Nattokinase Supplements

Cardiovascular Health

Nattokinase supplements are most commonly used to support heart health, particularly by improving the body’s ability to manage blood clot formation. Research has shown that the enzyme’s fibrinolytic activity helps break down excess fibrin, which can prevent the buildup of clots in the arteries and veins. This can reduce the risk of severe cardiovascular events such as heart attacks and strokes, especially for individuals with pre-existing heart conditions or those at higher risk due to lifestyle or genetic factors. By helping to keep blood vessels clear and preventing clot formation, nattokinase can also reduce the workload on the heart, potentially aiding in the regulation of blood pressure.

In addition to its clot-dissolving effects, nattokinase may offer a protective effect for individuals with hypertension. Some studies suggest that it can help lower blood pressure by improving blood viscosity and enhancing overall blood flow. When blood flows more easily through the vessels, it reduces the strain on the heart, which can lower systolic and diastolic blood pressure over time. While more research is needed to confirm these findings, early studies indicate that nattokinase could be a valuable supplement for individuals with hypertension or those seeking to maintain heart health naturally.

Improved Circulation

Nattokinase’s benefits extend beyond the heart to overall circulation. Many people suffer from poor blood flow, which can lead to conditions like deep vein thrombosis (DVT), leg cramps, or even chronic venous insufficiency. Nattokinase improves circulation by helping to dissolve proteins like fibrin that can cause blockages or slow down blood flow. This can lead to reduced swelling, better oxygen delivery to tissues, and decreased risk of circulatory issues. For those prone to DVT or varicose veins, nattokinase supplements could offer a preventative benefit by supporting smoother, unrestricted blood flow.

Moreover, enhanced circulation has a broader impact on overall health, including improved energy levels and cognitive function. Poor circulation can result in fatigue, cold extremities, and even cognitive decline due to insufficient blood reaching the brain. By promoting better blood flow, nattokinase can support better nutrient and oxygen delivery to tissues, contributing to overall vitality and well-being. It is also being studied for its potential to improve circulation in people with conditions like diabetes, which can cause complications related to poor blood flow.

Cholesterol Management

Although nattokinase is primarily known for its effects on blood clots, emerging research has started to explore its role in cholesterol management. High levels of LDL cholesterol, often called “bad” cholesterol, can lead to the buildup of plaque in the arteries, increasing the risk of atherosclerosis, heart disease, and stroke. Some studies suggest that nattokinase may help lower LDL cholesterol levels and prevent the formation of arterial plaques, although more research is needed to fully understand the mechanism behind these effects.

Early research has indicated that nattokinase may also reduce oxidative stress, a process that contributes to the oxidation of LDL cholesterol—a key step in the development of atherosclerosis. By inhibiting LDL oxidation, nattokinase may help slow the progression of plaque buildup in the arteries. While it is not a substitute for other cholesterol-lowering treatments like statins, nattokinase could offer a complementary approach for those looking to manage cholesterol naturally, particularly when combined with a heart-healthy diet and lifestyle changes.

Stroke Prevention

Ischemic strokes, which occur when blood clots block the flow of blood to the brain, are a leading cause of disability and death worldwide. Nattokinase’s ability to dissolve fibrin and reduce blood clot formation has made it a subject of interest in stroke prevention research. By reducing the likelihood of clot formation, nattokinase may lower the risk of ischemic strokes, making it a valuable preventative tool for individuals at higher risk due to conditions like hypertension, atrial fibrillation, or a history of strokes. Some studies have even suggested that nattokinase could help break down existing small clots, although more research is needed to confirm its effectiveness in this area.

It is important to note that while nattokinase may help reduce the risk of ischemic strokes, it should not be used as a replacement for conventional treatments, especially in individuals with significant cardiovascular risk factors. As a natural supplement, nattokinase offers a preventative approach, but it should be taken under medical supervision, particularly for those with a history of strokes or clotting disorders. Individuals on blood-thinning medications or those with a history of hemorrhagic strokes should consult a healthcare provider before taking nattokinase, as its blood-thinning properties could increase the risk of bleeding complications.

Common Uses of Nattokinase Supplements

Nattokinase supplements are primarily used by individuals who are concerned about their heart health or who are at risk for conditions like deep vein thrombosis (DVT) or other circulatory problems. Here are some of the most common reasons people take nattokinase supplements:

• Heart health maintenance: People with a family history of heart disease or individuals with existing cardiovascular concerns.
• Blood clot prevention: Those at risk for blood clot-related conditions, such as DVT or pulmonary embolism, may use nattokinase as a natural way to support circulation.
• Stroke risk reduction: For individuals with a higher risk of ischemic strokes, nattokinase supplements could be part of a preventative health regimen.

In the supplement market, nattokinase is available in several forms, including capsules and powders. Some products also combine nattokinase with other enzymes like serrapeptase to enhance its effects. Serrapeptase is another enzyme known for its anti-inflammatory properties, and when combined with Nattokinase, it may offer even broader health benefits.

Recommended Dosage and How to Take Nattokinase

For those considering nattokinase supplements, the dosage is typically measured in FU (fibrinolytic units), which reflects its enzymatic activity rather than weight. Most supplements contain between 2,000 to 4,000 FU per dose, equivalent to 100-200 mg of nattokinase. It’s recommended to follow the dosage instructions provided by the manufacturer or a healthcare professional.

Best Practices for Taking Nattokinase

• Take on an empty stomach: Nattokinase is absorbed more effectively when taken without food.
• Daily dosage: For general health, 2,000 to 4,000 FU per day is commonly recommended. However, those with specific health conditions should consult a doctor for personalized advice.
• Consider age and health condition: Older adults or individuals with specific health concerns may need to adjust the dosage based on their unique needs.

Potential Side Effects and Risks

Bleeding Risks

While nattokinase offers many cardiovascular benefits, one of the most significant risks associated with its use is its potential to increase bleeding. As a fibrinolytic enzyme, nattokinase actively breaks down fibrin, which is essential in forming blood clots. For individuals with clotting disorders or those taking anticoagulants like warfarin, nattokinase may amplify the blood-thinning effects, leading to excessive bleeding or difficulty clotting in the event of an injury. This can pose serious health risks, particularly for those undergoing surgery or those with conditions that make them prone to bleeding.

Individuals with bleeding disorders such as hemophilia, von Willebrand disease, or thrombocytopenia should avoid taking nattokinase unless specifically recommended by a healthcare professional. The same caution applies to people who are taking other medications or supplements that affect blood clotting, such as aspirin, fish oil, or vitamin E. The risk of excessive bleeding underscores the importance of consulting a doctor before starting nattokinase, especially for those with pre-existing health conditions or those on blood-thinning medications.

Interaction with Medications

Nattokinase’s role as a blood-thinning enzyme means it can interact with a range of medications, particularly those used to manage cardiovascular conditions. For individuals taking anticoagulants like warfarin, heparin, or even over-the-counter medications like aspirin, adding nattokinase to their routine could increase the risk of serious bleeding. This interaction is due to nattokinase enhancing the blood-thinning effects of these medications, potentially leading to a higher risk of internal bleeding, bruising, or prolonged bleeding from minor injuries.

It is not just blood thinners that can interact with nattokinase. Medications used to lower blood pressure, such as ACE inhibitors or beta-blockers, may also be affected, as nattokinase has the potential to lower blood pressure further. This could lead to dizziness, fainting, or other symptoms of low blood pressure (hypotension). Individuals taking medications for heart disease, high blood pressure, or clotting disorders should speak with their doctor before taking nattokinase to avoid adverse drug interactions.

Allergic Reactions

Because nattokinase is derived from fermented soybeans, individuals with soy allergies should approach it with caution. While the enzyme is usually extracted and purified, trace amounts of soy protein may remain in the supplement, potentially triggering allergic reactions in sensitive individuals. Symptoms of a soy allergy can range from mild reactions, such as itching or hives, to more severe reactions like anaphylaxis, which requires immediate medical attention.

For individuals concerned about soy allergies, it’s important to look for nattokinase supplements that clearly state they are soy-free or to consult a healthcare provider before use. Although soy allergies are relatively rare, the potential for an allergic reaction remains, especially for those with a history of food allergies. It’s always a good idea to start with a low dose and monitor for any signs of an allergic response before incorporating nattokinase into a regular supplement routine.

Who Should Avoid Nattokinase?

Not everyone can safely take nattokinase supplements. Some individuals are at a higher risk for side effects and should avoid this enzyme, including:

• Pregnant or breastfeeding women: The effects of nattokinase during pregnancy and breastfeeding are not well-studied, so it’s best to avoid use.
• People with bleeding disorders: Individuals with conditions like hemophilia or other clotting disorders may experience increased bleeding risks.
• Those on anticoagulants: Since nattokinase can enhance the effects of blood-thinning medications, it’s not recommended for people already taking anticoagulants.
• Upcoming surgery: Anyone scheduled for surgery should avoid nattokinase in the weeks leading up to the procedure to prevent excessive bleeding during surgery.

For these groups, consulting a healthcare provider before taking nattokinase is essential to avoid complications.

Choosing the Best Nattokinase Supplement

When shopping for nattokinase supplements, it’s important to prioritize quality to ensure you're getting the most effective product. Here are a few factors to consider:

• Purity: Choose a supplement that contains pure nattokinase without unnecessary fillers or additives.
• Enzyme activity: Look for supplements that list their nattokinase content in FU (fibrinolytic units) to measure its effectiveness.
• Third-party testing: Opt for products that have been independently tested for quality and potency.
• Reputable brands: Consider well-known brands with good reviews and certifications, such as non-GMO or vegan options, if those are important to you.

Conclusion

Nattokinase offers promising benefits for cardiovascular health, from reducing the risk of blood clots to improving circulation. However, like any supplement, it’s crucial to use it responsibly, following dosage guidelines and understanding the potential risks.

At Health Orchard, we offer a range of high-quality nattokinase supplements that are rigorously tested for purity and potency. Shop with us to find the best prices and compare top brands, including Walmart, Amazon, iHerb, and more. Prioritize your heart health with reliable supplements and make informed decisions about your wellness.

Start your journey toward better cardiovascular health today with Health Orchard!

Frequently Asked Questions about Nattokinase Supplements

1. What does nattokinase supplement do?

Nattokinase is an enzyme derived from natto (fermented soybeans) that may help support cardiovascular health. It's believed to promote healthy blood flow by breaking down fibrin, a protein involved in blood clotting. Some studies suggest it may help maintain normal blood pressure and reduce the risk of blood clots.

2. What are the negative side effects of nattokinase?

Potential side effects of nattokinase include gastrointestinal discomfort, diarrhea, and headaches. It may increase bleeding risk, especially when combined with blood-thinning medications. Some people may experience allergic reactions. It's important to consult a healthcare provider before taking nattokinase, particularly if you have pre-existing health conditions or are on medications.

3. Does nattokinase clean arteries?

While nattokinase isn't proven to "clean" arteries, some research suggests it may support cardiovascular health. It may help break down fibrin and reduce the formation of blood clots, potentially aiding in maintaining arterial health. However, more comprehensive studies are needed to confirm its effectiveness in directly cleaning or unclogging arteries.

4. What foods are high in nattokinase?

Nattokinase is primarily found in natto, a traditional Japanese food made from fermented soybeans. It's not naturally present in significant amounts in other foods. While other fermented soy products like tempeh or miso contain beneficial enzymes, they don't specifically contain nattokinase. For substantial nattokinase intake, natto or supplements are the primary sources.

5. Should nattokinase be taken daily?

The decision to take nattokinase daily should be made in consultation with a healthcare provider. While some studies have shown potential benefits from daily use, long-term safety and optimal dosage are not fully established. Factors like individual health status, medications, and specific health goals should be considered before starting a daily regimen.

6. Is nattokinase good for the liver?

There's limited research on nattokinase's direct effects on liver health. Some studies suggest it may have anti-inflammatory properties that could benefit overall health, including liver function. However, more specific research is needed to determine its direct impact on liver health. As with any supplement, consult a healthcare provider before use.

7. Who should not eat natto?

Individuals on blood-thinning medications should avoid natto or consult their doctor before consuming it, as it may increase bleeding risk. Those with soy allergies should also avoid natto. People with certain gastrointestinal conditions may need to be cautious. Pregnant or breastfeeding women should consult their healthcare provider before consuming natto regularly.

8. Is nattokinase safe for kidney disease?

The safety of nattokinase for individuals with kidney disease is not well-established. While some studies suggest potential benefits for cardiovascular health, which can be important for kidney patients, there's insufficient research on its direct effects on kidney function. Patients with kidney disease should consult their nephrologist before taking nattokinase.

9. What vitamin is natto high in?

Natto is particularly high in vitamin K2, specifically menaquinone-7 (MK-7). This form of vitamin K is important for bone health and may have cardiovascular benefits. Natto is one of the richest dietary sources of vitamin K2. It also contains other nutrients like protein, fiber, and various minerals.

10. Is nattokinase the same as vitamin K?

No, nattokinase and vitamin K are different substances. Nattokinase is an enzyme derived from natto, while vitamin K is a fat-soluble vitamin. However, natto, the food from which nattokinase is derived, is also rich in vitamin K2. These two components of natto have different functions in the body and are not interchangeable.

References

• Nutrition Research, "Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects", March 2009.
• Verywell Health, "Does Nattokinase Have a Role in Supporting Heart Health?", September 2024.
• IMR Press, "Nattokinase Supplementation and Cardiovascular Risk Factors", August 2023.
• WebMD, “Health Benefits of Nattokinase”, November 2022.
• Examine, “Nattokinase benefits, dosage, and side effects”, July 2024.
• RxList, “Nattokinase”, June 2021.
• Frontiers in Cardiovascular Medicine, “Effective management of atherosclerosis progress and hyperlipidemia with nattokinase”, August 2022.
• Healthline, “Why Natto Is Super Healthy and Nutritious”, January 2023.
• Pure Prescriptions, “Nattokinase: A Heart-Healthy Ally For Cardiovascular Health”, December 2023.
• Fermentation, “Nattokinase: Insights into Biological Activity, Therapeutic Applications, and the Influence of Microbial Fermentation”, November 2023.